Utility of magnifying endoscopy with narrow band imaging in determining the invasion depth of superficial pharyngeal cancer

Head Neck. 2015 Jun;37(6):846-50. doi: 10.1002/hed.23683. Epub 2014 Jun 27.

Abstract

Background: Magnifying endoscopy with narrow band imaging (ME-NBI) is useful to diagnose invasion depth of superficial esophageal cancer. The purpose of this study was to evaluate the utility of ME-NBI of superficial pharyngeal cancer.

Methods: Between April 2008 and June 2012, 146 lesions in 104 patients who underwent ME-NBI and en bloc resection were retrospectively analyzed. Based on magnifying endoscopic classification, proposed by the Japan Esophageal Society, microvasculature type was classified into B1, B2, and B3.

Results: B1 alone, B2, and B3 were observed in 128, 14, and 4 lesions, respectively. The frequency of subepithelial cancer were 20.3% (26 of 128), 78.6% (11 of 14), and 100% (4 of 4), respectively (p < .05). Mean invasion distance were 650 μm, 720.0 μm, and 2256.5 μm. Positive and negative predictive value for diagnosing subepithelial cancer based on the presence of B2 or B3 was 83.3% (15 of 18) and 79.7% (102 of 128).

Conclusion: ME-NBI is useful to determining invasion depth of superficial pharyngeal cancer.

Keywords: invasion depth; magnified endoscopy; narrow band imaging; squamous cell carcinoma; superficial pharyngeal cancer.

MeSH terms

  • Aged
  • Carcinoma, Squamous Cell / diagnosis
  • Carcinoma, Squamous Cell / pathology*
  • Carcinoma, Squamous Cell / surgery
  • Cohort Studies
  • Female
  • Head and Neck Neoplasms / diagnosis
  • Head and Neck Neoplasms / pathology*
  • Head and Neck Neoplasms / surgery
  • Humans
  • Image Enhancement / methods*
  • Laryngoscopy / methods*
  • Male
  • Middle Aged
  • Narrow Band Imaging*
  • Neoplasm Invasiveness / pathology
  • Neoplasm Staging
  • Pharyngeal Neoplasms / diagnosis
  • Pharyngeal Neoplasms / pathology*
  • Pharyngeal Neoplasms / surgery
  • Retrospective Studies
  • Sensitivity and Specificity
  • Squamous Cell Carcinoma of Head and Neck
  • Statistics, Nonparametric