Abstract
Twelve new lactam-bearing limonoids, amooramides A-L (1-12), were isolated from the twigs and leaves of Amoora tsangii, and their structures fully elucidated by spectroscopic analysis. These compounds represent the first examples of rings A,B-seco-limonoids bearing unusual lactam side chains at C-17, including a 3-substituted 1,5-dihydro-2H-pyrrol-2-one moiety in 1-7 and a 4-substituted 1,5-dihydro-2H-pyrrol-2-one unit in 8-12. Compound 9 inhibited TNFα-induced NF-κB activity by 64% at a concentration of 10 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Drugs, Chinese Herbal / chemistry*
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Hep G2 Cells
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Humans
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Lactams / chemistry
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Lactams / isolation & purification*
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Lactams / pharmacology
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Limonins / chemistry*
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Limonins / isolation & purification*
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Limonins / pharmacology
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Meliaceae / chemistry*
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Molecular Structure
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NF-kappa B / antagonists & inhibitors
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Nuclear Magnetic Resonance, Biomolecular
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Plant Leaves / chemistry
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Plant Stems / chemistry
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Drugs, Chinese Herbal
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Lactams
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Limonins
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NF-kappa B
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Tumor Necrosis Factor-alpha