Abstract
Benzoselenadiazole-containing inhibitors of protein kinases were constructed and their capability to emit phosphorescence in the kinase-bound state was established. Labelling of the inhibitors with a red fluorescent dye led to sensitive responsive photoluminescent probes for protein kinase CK2 that emitted red light with a long (microsecond-scale) decay time upon excitation of the probes with a pulse of near-UV light.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Azoles / chemistry*
-
Azoles / radiation effects
-
Casein Kinase II / chemistry*
-
Coloring Agents / chemistry*
-
Coloring Agents / radiation effects
-
Cyclic AMP-Dependent Protein Kinases / chemistry
-
Light
-
Organoselenium Compounds / chemistry*
-
Organoselenium Compounds / radiation effects
-
Peptides / chemistry*
-
Peptides / radiation effects
-
Proto-Oncogene Proteins c-pim-1 / chemistry
Substances
-
Azoles
-
Coloring Agents
-
Organoselenium Compounds
-
Peptides
-
Casein Kinase II
-
Proto-Oncogene Proteins c-pim-1
-
Cyclic AMP-Dependent Protein Kinases