Cinanthrenol A, an estrogenic steroid containing phenanthrene nucleus, from a marine sponge Cinachyrella sp

Koshi Machida; Takahiro Abe; Daisuke Arai; Mayumi Okamoto; Isao Shimizu; Nicole J de Voogd; Nobuhiro Fusetani; Yoichi Nakao

doi:10.1021/ol5000023

Cinanthrenol A, an estrogenic steroid containing phenanthrene nucleus, from a marine sponge Cinachyrella sp

Org Lett. 2014 Mar 21;16(6):1539-41. doi: 10.1021/ol5000023. Epub 2014 Mar 12.

Authors

Koshi Machida¹, Takahiro Abe, Daisuke Arai, Mayumi Okamoto, Isao Shimizu, Nicole J de Voogd, Nobuhiro Fusetani, Yoichi Nakao

Affiliation

¹ School of Advanced Science and Engineering, Waseda University , Shinjuku-ku, Tokyo 169-8555, Japan.

PMID: 24617666
DOI: 10.1021/ol5000023

Abstract

Cinanthrenol A (1), a new steroid composed of a phenanthrene and a spiro[2,4]heptane system, was isolated from the marine sponge Cinachyrella sp. It is the first phenathrene-containing steroid with estrogen activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Estrogens / chemistry
Estrogens / isolation & purification*
Estrogens / pharmacology*
Humans
Marine Biology
Molecular Structure
Phenanthrenes / chemistry*
Porifera / chemistry*
Steroids / chemistry
Steroids / isolation & purification*
Steroids / pharmacology*

Substances

Estrogens
Phenanthrenes
Steroids
cinanthrenol A
phenanthrene