Ruthenium-catalyzed C7 amidation of indoline C-H bonds with sulfonyl azides

Abstract

A ruthenium-catalyzed direct C7 amidation of indoline C-H bonds with sulfonyl azides was developed. This procedure allows the synthesis of a variety of 7-amino-substituted indolines, which are useful in pharmaceutical. The good functional tolerances, as well as the mild conditions, are prominent feature of this method.

Keywords: CH activation; amidation; indolines; ruthenium; sulfonyl azides.