A novel hybrid metal-organic framework-polymeric monolith for solid-phase microextraction

Chen-Lan Lin; Stephen Lirio; Ya-Ting Chen; Chia-Her Lin; Hsi-Ya Huang

doi:10.1002/chem.201304458

A novel hybrid metal-organic framework-polymeric monolith for solid-phase microextraction

Chemistry. 2014 Mar 17;20(12):3317-21. doi: 10.1002/chem.201304458. Epub 2014 Feb 24.

Authors

Chen-Lan Lin¹, Stephen Lirio, Ya-Ting Chen, Chia-Her Lin, Hsi-Ya Huang

Affiliation

¹ Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, Chung-Li, 320 (Taiwan).

PMID: 24615770
DOI: 10.1002/chem.201304458

Abstract

This study describes the fabrication of a novel hybrid metal-organic framework- organic polymer (MOF-polymer) for use as a stationary phase in fritless solid-phase microextraction (SPME) for validating analytical methods. The MOF-polymer was prepared by using ethylene dimethacrylate (EDMA), butyl methacrylate (BMA), and an imidazolium-based ionic liquid as porogenic solvent followed by microwave-assisted polymerization with the addition of 25 % MOF. This novel hybrid MOF-polymer was used to extract penicillin (penicillin G, penicillin V, oxacillin, cloxacillin, nafcillin, dicloxacillin) under different conditions. Quantitative analysis of the extracted penicillin samples using the MOF-organic polymer for SPME was conducted by using capillary electrochromatography (CEC) coupled with UV analysis. The penicillin recovery was 63-96.2 % with high reproducibility, sensitivity, and reusability. The extraction time with the proposed fabricated SPME was only 34 min.

Keywords: capillary electrochromatography; metal-organic frameworks; penicillin; polymers; solid-phase microextraction.