Anti-HIV-1 tigliane diterpenoids from Excoecaria acertiflia Didr

Fitoterapia. 2014 Jun:95:34-41. doi: 10.1016/j.fitote.2014.02.018. Epub 2014 Mar 5.

Abstract

Three tigliane-type diterpenoids named excoecafolins A-C and two daphnane-type diterpenoids named excoecafolins D and E, together with 13 known compounds, were isolated from the EtOAc extract of Excoecaria acerifolia Didr. Their structures were elucidated through the analysis of the spectroscopic data. The anti-HIV-1 activity evaluation of five of these compounds showed that four possessed moderate anti-HIV-1 activities with EC50 0.258, 0.036, 0.046, and 0.978 μM, SI >1,836.9, 431.1, 298.7, and >503.7, respectively. Additionally, the chemotaxonomic issue of the affinity correlation between Thymelaeceae and Euphorbiaceae is discussed based on the isolates.

Keywords: 4-O-methyl-TPA (PubChem CID 72292); Anti-HIV-1; Chemotaxonomy; Euphorbiaceae; Excoecafolin; Excoecaria acerifolia; caryolanel,9β-diol (PubChem CID 44559977); catechin (PubChem CID 9064); daphneticin (PubChem CID 158341); dapneolon (PubChem CID 5316300); excoecariatoxin (PubChem CID 6442008); schisanwilsonene A (PubChem CID 56671370).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / isolation & purification*
  • Anti-HIV Agents / pharmacology
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Euphorbiaceae / chemistry*
  • HIV-1 / drug effects*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Stems / chemistry
  • Plants, Medicinal

Substances

  • Anti-HIV Agents
  • Diterpenes
  • Drugs, Chinese Herbal
  • mezerein