Dehydroepiandrosterone sulfate and cognition in midlife, post-menopausal women

Charlene K Z Chua; Victor W Henderson; Lorraine Dennerstein; David Ames; Cassandra Szoeke

doi:10.1016/j.neurobiolaging.2014.01.140

Dehydroepiandrosterone sulfate and cognition in midlife, post-menopausal women

Neurobiol Aging. 2014 Jul;35(7):1654-5. doi: 10.1016/j.neurobiolaging.2014.01.140. Epub 2014 Jan 31.

Authors

Charlene K Z Chua¹, Victor W Henderson², Lorraine Dennerstein³, David Ames⁴, Cassandra Szoeke⁵

Affiliations

¹ Department of Medicine, University of Melbourne, Parkville, Victoria, Australia.
² Department of Health Research and Policy (Epidemiology), Stanford University, Stanford, CA, USA; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
³ Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia.
⁴ National Ageing Research Institute, Parkville, Victoria, Australia.
⁵ Department of Medicine, University of Melbourne, Parkville, Victoria, Australia. Electronic address: cszoeke@unimelb.edu.au.

PMID: 24612674
DOI: 10.1016/j.neurobiolaging.2014.01.140

Abstract

The association between serum dehydroepiandrosterone sulfate (DHEAS) and cognition was assessed in 218 healthy, midlife, post-menopausal women, aged 55-65 years. In cross-sectional analyses, DHEAS level was not significantly associated with a standardized score of global cognition or with individual test scores from a comprehensive neuropsychological battery (all p-values >0.05). In longitudinal analyses of 176 women, DHEAS level was unassociated with cognition 2 years later or with 2-year change in cognition. These findings fail to support the view that DHEAS is substantially related to cognitive function in midlife, post-menopausal women.

Keywords: Cognition; Dehydroepiandrosterone sulfate; Menopause; Midlife; Women.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cognition*
Cross-Sectional Studies
Dehydroepiandrosterone / blood*
Female
Humans
Longitudinal Studies
Middle Aged
Neuropsychological Tests
Postmenopause / blood*
Postmenopause / psychology*
Time Factors

Substances

Dehydroepiandrosterone