A convenient semisynthesis of myricetin-3-O-β-d-glucuronide

J Asian Nat Prod Res. 2014;16(5):522-6. doi: 10.1080/10286020.2014.895715. Epub 2014 Mar 11.

Abstract

Myricetin-3-O-β-d-glucuronide, a bioactive flavonol glycoside, was synthesized effectively starting from myricetrin in a total yield of 49.2%. The structures of all synthetic compounds were confirmed by (1)H, (13)C NMR, and HR-MS techniques.

Keywords: 3′,4′,5′,5,7-penta-O-benzylmyricetin; myricetin-3-O-β-d-glucuronide; semisynthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Flavonoids / chemical synthesis*
  • Flavonoids / chemistry
  • Flavonols / chemistry
  • Glucuronides / chemical synthesis*
  • Glucuronides / chemistry
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Stereoisomerism

Substances

  • Flavonoids
  • Flavonols
  • Glucuronides
  • myricetin
  • myricetin 3-O-glucuronide