A ligation DNAzyme-induced magnetic nanoparticles assembly for ultrasensitive detection of copper ions

Honghong Yin; Hua Kuang; Liqiang Liu; Liguang Xu; Wei Ma; Libing Wang; Chuanlai Xu

doi:10.1021/am405482a

A ligation DNAzyme-induced magnetic nanoparticles assembly for ultrasensitive detection of copper ions

ACS Appl Mater Interfaces. 2014 Apr 9;6(7):4752-7. doi: 10.1021/am405482a. Epub 2014 Mar 19.

Authors

Honghong Yin¹, Hua Kuang, Liqiang Liu, Liguang Xu, Wei Ma, Libing Wang, Chuanlai Xu

Affiliation

¹ State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University , Wuxi, Jiangsu 214122, China.

PMID: 24611502
DOI: 10.1021/am405482a

Abstract

A novel biosensor for ultrasensitive detection of copper (Cu(2+)) was established based on the assembly of magnetic nanoparticles induced by the Cu(2+)-dependent ligation DNAzyme. With a low limit of detection of 2.8 nM and high specificity, this method has the potential to serve as a general platform for the detection of heavy metal ions.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques / instrumentation
Biosensing Techniques / methods*
Copper / analysis*
DNA, Catalytic / chemistry*
DNA, Catalytic / genetics
Drinking Water / analysis*
Ions / analysis
Magnetite Nanoparticles / chemistry*
Sensitivity and Specificity
Water Pollutants, Chemical / analysis*

Substances

DNA, Catalytic
Drinking Water
Ions
Magnetite Nanoparticles
Water Pollutants, Chemical
Copper