Total synthesis of nucleoside antibiotic A201A

Shenyou Nie; Wei Li; Biao Yu

doi:10.1021/ja501460j

Total synthesis of nucleoside antibiotic A201A

J Am Chem Soc. 2014 Mar 19;136(11):4157-60. doi: 10.1021/ja501460j. Epub 2014 Mar 11.

Authors

Shenyou Nie¹, Wei Li, Biao Yu

Affiliation

¹ State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , Shanghai 200032, China.

PMID: 24611434
DOI: 10.1021/ja501460j

Abstract

A201A, a unique nucleoside antibiotic with potent antibacterial activities, has been synthesized for the first time in a total of 47 steps in a highly modular and linear manner, highlighting the elaboration/incorporation of an unprecedented hexofuranoside unit bearing an exocyclic enol ether moiety.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aminoglycosides / chemical synthesis*
Aminoglycosides / chemistry
Molecular Conformation

Substances

Aminoglycosides
A 201A