Microfluidic-assisted self-assembly of complex dendritic polyethylene drug delivery nanocapsules

Adv Mater. 2014 May 21;26(19):3118-23. doi: 10.1002/adma.201305753. Epub 2014 Mar 7.

Abstract

Microfluidic platform for the synthesis of complex nanocapsules is presented via a controlled self-assembly. The monodisperse nanocapsules in the range of 50-200 nm consist of a dendritic polyethylene core and a Pluronic copolymer shell. The resultant nanocarriers encapsulate large amount of hydrophobic anticancer drug like paclitaxel while providing a low complement activation as well as sustained release profile with high tunability.

Keywords: cancer therapeutics; controlled drug delivery; hyperbranched polyethylene nanocapsule; microfluidic-assisted self-assembly; paclitaxel.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / toxicity
  • Cell Line
  • Cell Survival / drug effects
  • Dendrimers / chemistry*
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • MCF-7 Cells
  • Macrophages / cytology
  • Macrophages / immunology
  • Mice
  • Microfluidic Analytical Techniques*
  • Nanocapsules / chemistry*
  • Paclitaxel / chemistry
  • Paclitaxel / toxicity
  • Particle Size
  • Phagocytosis
  • Polyethylene / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Dendrimers
  • Nanocapsules
  • Polyethylene
  • Paclitaxel