Primary acute dengue and the deletion in chemokine receptor 5 (CCR5Δ32)

Brian Brestovac; Larissa A Halicki; Ryan P Harris; Ian Sampson; David J Speers; Cyril Mamotte; David Williams

doi:10.1016/j.micinf.2014.02.007

Primary acute dengue and the deletion in chemokine receptor 5 (CCR5Δ32)

Microbes Infect. 2014 Jun;16(6):518-21. doi: 10.1016/j.micinf.2014.02.007. Epub 2014 Mar 4.

Authors

Brian Brestovac¹, Larissa A Halicki², Ryan P Harris², Ian Sampson³, David J Speers⁴, Cyril Mamotte², David Williams⁵

Affiliations

¹ School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, Western Australia 6845, Australia. Electronic address: B.Brestovac@curtin.edu.au.
² School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, Western Australia 6845, Australia.
³ Department of Microbiology, Pathwest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia.
⁴ Department of Microbiology, Pathwest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia; School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia 6009, Australia.
⁵ School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, Western Australia 6845, Australia; Department of Microbiology, Pathwest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6009, Australia.

PMID: 24607451
DOI: 10.1016/j.micinf.2014.02.007

Abstract

Dengue virus is a significant arboviral pathogen that is continuing to spread due to human travel and invasion of the mosquito vectors into new regions. Chemokine receptor 5 (CCR5) has a truncated 32 base pair deletion form (CCR5Δ32), which has been associated with resistance to HIV but increased severity in some flaviviral diseases. If CCR5Δ32 is associated with dengue, European carriers of this mutation may be at increased risk. In a Western Australian population with the same frequency of CCR5Δ32 (0.08) as that found in southern Europe there was no significant difference in CCR5Δ32 allele frequency between returned travellers with and without dengue (p = 0.82, OR = 0.86, 95% CI = 0.35-2.1).

Keywords: Cysteine–cysteine chemokine receptor 5 (CCR5); Cysteine–cysteine chemokine receptor 5–32 base deletion (CCR5Δ32); Dengue virus (DENV); Flavivirus; Vector.

MeSH terms

Acute Disease
Case-Control Studies
Dengue / genetics*
Gene Frequency
Genetic Predisposition to Disease
Humans
Mutation
Receptors, CCR5 / genetics*
Sequence Deletion*
Western Australia

Substances

Receptors, CCR5