Heps with pep: direct reprogramming into human hepatocytes

Cell Stem Cell. 2014 Mar 6;14(3):267-9. doi: 10.1016/j.stem.2014.02.010.

Abstract

The limited supply and expansion capacity of primary human hepatocytes presents major challenges for pharmaceutical applications and development of cell-based therapies for liver diseases. Now in Cell Stem Cell, two papers demonstrate efficient direct reprogramming of human fibroblasts into induced hepatocytes, which exhibit metabolic properties similar to primary hepatocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Cell Lineage*
  • Cellular Reprogramming*
  • Fibroblasts / cytology*
  • Hepatocytes / cytology*
  • Hepatocytes / metabolism*
  • Humans