Screening and early detection of pancreatic cancer in high risk population

World J Gastroenterol. 2014 Mar 7;20(9):2358-64. doi: 10.3748/wjg.v20.i9.2358.

Abstract

Pancreatic cancer is a serious growing health issue in developed countries. For patients diagnosed with pancreatic cancer, the five year survival rate is below 5%. One major important reason leads to the poor survival rate is lack of early detection of pancreatic cancer. Over 80% of the patients are diagnosed in advanced disease stages. Screening for pancreatic cancer is a desirable option for high risk individuals to allow early detection and treatment of curable pancreatic neoplasms at a pre-invasive stage. This article highlights the need, endpoint, population, method, diagnostic yield, and the problems of current screening programs.

Keywords: High risk population; Pancreatic cancer screening; Pancreatic neoplasm; Peutz-Jeghers syndrome.

Publication types

  • Review

MeSH terms

  • Diagnostic Imaging / methods*
  • Early Detection of Cancer / methods*
  • Humans
  • Pancreatic Neoplasms / diagnosis*
  • Pancreatic Neoplasms / epidemiology
  • Pancreatic Neoplasms / therapy
  • Patient Selection
  • Predictive Value of Tests
  • Prognosis
  • Risk Assessment
  • Risk Factors
  • Time Factors