Pd-catalyzed branching cyclizations of enediyne-imides toward furo[2,3-b]pyridines

Org Lett. 2014 Mar 21;16(6):1822-5. doi: 10.1021/ol500574b. Epub 2014 Mar 6.

Abstract

The convergent synthesis of a class of enediyne-imides as well as their palladium-catalyzed branching cyclizations, which can be accomplished in two ways leading to a set of polysubstituted furo[2,3-b]pyridines upon using the N-tosyl carboxamide moiety as an N,O-bisnucleophile, are presented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Combinatorial Chemistry Techniques
  • Cyclization
  • Furans / chemical synthesis*
  • Furans / chemistry
  • Heterocyclic Compounds, 2-Ring / chemical synthesis*
  • Heterocyclic Compounds, 2-Ring / chemistry
  • Imides / chemistry*
  • Molecular Structure
  • Palladium / chemistry*
  • Pyridines / chemical synthesis*
  • Pyridines / chemistry

Substances

  • Furans
  • Heterocyclic Compounds, 2-Ring
  • Imides
  • Pyridines
  • Palladium