This study investigated the aerobic degradation ofbisphenol-A (BPA) and the derivatives bisphenol-B (BPB), bisphenol-F (BPF), tetrabromobisphenol-A (TBBPA), and tetrachlorobisphenol-A (TCBPA) in river sediment. The degradation rates of BPA and BPF were enhanced by adding brij 30, brij 35, rhamnolipid, surfactin, or crude enzyme; a higher degradation rate was observed with crude enzyme than with the other additives. The degradation rates of BPA and its derivatives (BPAs) in the sediment were BPF > BPA > BPB > TCBPA > TBBPA. Different BPAs affected the changes in the microbial community in the sediment. Sediment fractions with larger particle sizes demonstrated higher degradation rates. Different sediment particle sizes affected the changes in the microbial communities. Pseudomonas sp. may be the dominant bacteria in the process of degradation of BPAs in river sediment.