Fatty liver and serum cholinesterase are independently correlated with HbA1c levels: cross-sectional analysis of 5384 people

J Int Med Res. 2014 Apr;42(2):542-53. doi: 10.1177/0300060513517485. Epub 2014 Mar 4.

Abstract

Objectives: To examine the association between glycosylated haemoglobin (HbA1c) and fatty liver markers.

Methods: This cross-sectional analysis stratified subjects into quintiles based on HbA1c. Fatty liver using ultrasonography scores (FLUS) were assigned as follows: 2 points, moderate or severe fatty liver; 1 point, mild fatty liver; and 0 points, normal liver. Subjects with viral hepatitis, alcohol intake >175 g/week or receiving hypoglycaemic treatment were excluded.

Results: The study included 5384 subjects. Serum cholinesterase (ChE) and FLUS showed a significant graded increase with increasing HbA1c. In linear regression analysis stratified by body mass index (BMI) and age, ChE and FLUS were significantly associated with lower (1 + 2) and higher (3 + 4 + 5) HbA1c quintiles, respectively, independent of BMI and age.

Conclusions: The findings show that both ChE and FLUS are significantly correlated with HbA1c, independent of BMI and age.

Keywords: Cholinesterase; HbA1c; non-alcoholic fatty liver disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Body Composition
  • Body Mass Index
  • Cholinesterases / blood*
  • Cross-Sectional Studies
  • Fatty Liver / blood*
  • Fatty Liver / diagnostic imaging*
  • Female
  • Glycated Hemoglobin / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Ultrasonography
  • Young Adult

Substances

  • Biomarkers
  • Glycated Hemoglobin A
  • hemoglobin A1c protein, human
  • Cholinesterases