This issue of the Journal highlights the problem-solving perspectives of primary care practices, including practice-based research networks. Informed, dedicated primary care teams are seeking incremental insight on how to use health information technology to support holistic enhancements in primary care, including how health information technology can support individual patients and how it can support care teams. Practice-based research networks comprise groups of primary care clinicians, their diversified practice teams, and skilled researchers, all of whom work together to answer community-based health care questions, seek practical solutions, and translate research findings into practice.