Association between polymorphisms in OAS2 and CD209 genes and predisposition to chronic hepatitis C in Russian population

Microbes Infect. 2014 May;16(5):445-9. doi: 10.1016/j.micinf.2014.02.004. Epub 2014 Mar 1.

Abstract

Chronic hepatitis C is a severe liver disease caused by positive-strand RNA virus. Previously, we reported an association between seven single nucleotide polymorphisms (SNPs) in four innate immunity genes (OAS2, OAS3, CD209, and TLR3) and human predisposition to tick-borne encephalitis, caused by a virus from the same Flaviviridae family, in a Russian population. Currently, genotype and allele frequencies for these SNPs were analyzed in 75 chronic hepatitis C patients and compared with the population control (269 Novosibirsk citizens). Data obtained suggest that the OAS2 rs1293762 and CD209 rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population.

Keywords: Chronic hepatitis C; Genetic predisposition to disease; Single nucleotide polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2',5'-Oligoadenylate Synthetase / genetics*
  • Adolescent
  • Adult
  • Cell Adhesion Molecules / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genotype
  • Hepatitis C, Chronic / epidemiology*
  • Humans
  • Lectins, C-Type / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Receptors, Cell Surface / genetics*
  • Russia
  • Young Adult

Substances

  • Cell Adhesion Molecules
  • DC-specific ICAM-3 grabbing nonintegrin
  • Lectins, C-Type
  • Receptors, Cell Surface
  • 2',5'-Oligoadenylate Synthetase