Antiangiogenic activity of hypoxylonol C

Miyuki Fukai; Toshihiro Suzuki; Ikuko Nagasawa; Kaoru Kinoshita; Kunio Takahashi; Kiyotaka Koyama

doi:10.1021/np400687y

Antiangiogenic activity of hypoxylonol C

J Nat Prod. 2014 Apr 25;77(4):1065-8. doi: 10.1021/np400687y. Epub 2014 Mar 4.

Authors

Miyuki Fukai¹, Toshihiro Suzuki, Ikuko Nagasawa, Kaoru Kinoshita, Kunio Takahashi, Kiyotaka Koyama

Affiliation

¹ Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University , Noshio 2-522-1 Kiyose-shi, Tokyo 204-8588, Japan.

PMID: 24593182
DOI: 10.1021/np400687y

Abstract

Hypoxylonol C (1), isolated from the inedible mushroom Hypoxylon truncatum, exhibited inhibitory activities against the migration and tube formation of HUVECs. A cDNA microarray analysis was performed to investigate the target of hypoxylonol C (1) in HUVECs, and it was found that the genes related to cell cycle and adhesion were down-regulated. The down-regulation of mRNA levels of cell cycle and adhesion genes was confirmed by real-time RT-PCR. Cell cycle arrest and suppression of adhesion molecule expression might be plausible mechanisms of actions for the antiangiogenic activity of hypoxylonol C (1).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiogenesis Inhibitors / genetics
Angiogenesis Inhibitors / isolation & purification*
Angiogenesis Inhibitors / pharmacology*
Apoptosis / drug effects
Cell Adhesion / drug effects
Cell Cycle / drug effects
Cell Movement / drug effects
Cell Proliferation / drug effects
Dose-Response Relationship, Drug
Fluorenes / chemistry
Fluorenes / isolation & purification*
Fluorenes / pharmacology*
Human Umbilical Vein Endothelial Cells / drug effects
Humans
Molecular Structure
Vascular Endothelial Growth Factor A / pharmacology

Substances

Angiogenesis Inhibitors
Fluorenes
Vascular Endothelial Growth Factor A
hypoxylonol C