A,D-seco-limonoids from the stems of Clausena emarginata

J Nat Prod. 2014 Apr 25;77(4):784-91. doi: 10.1021/np400797s. Epub 2014 Mar 4.

Abstract

Twelve new A,D-seco-limonoids, clauemargines A-L (1-12), and three known analogues were isolated from the stems of Clausena emarginata. The absolute configurations of 1 and 5 were confirmed by X-ray crystallography and ECD spectroscopy, respectively. Compounds 1, 2, 8-10, and 13 showed moderate inhibitory effects on LPS-induced NO production (IC50 values<10 μM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Clausena / chemistry*
  • Crystallography, X-Ray
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Hep G2 Cells
  • Humans
  • Inhibitory Concentration 50
  • Limonins / chemistry
  • Limonins / isolation & purification*
  • Limonins / pharmacology
  • Lipopolysaccharides / pharmacology
  • Macrophages / drug effects
  • Meliaceae / chemistry*
  • Mice
  • Molecular Conformation
  • Molecular Structure
  • Nitric Oxide / biosynthesis
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Stems / chemistry

Substances

  • Drugs, Chinese Herbal
  • Limonins
  • Lipopolysaccharides
  • Nitric Oxide