Brønsted acid catalyzed cascade reactions of 2-[(2-aminophenyl)ethynyl]phenylamine derivatives with aldehydes: a new approach to the synthesis of 2,2'-disubstituted 1H,1'H-3,3'-biindoles

Antonio Arcadi; Marco Chiarini; Gaetano D'Anniballe; Fabio Marinelli; Emanuela Pietropaolo

doi:10.1021/ol500401p

Brønsted acid catalyzed cascade reactions of 2-[(2-aminophenyl)ethynyl]phenylamine derivatives with aldehydes: a new approach to the synthesis of 2,2'-disubstituted 1H,1'H-3,3'-biindoles

Org Lett. 2014 Mar 21;16(6):1736-9. doi: 10.1021/ol500401p. Epub 2014 Mar 3.

Authors

Antonio Arcadi¹, Marco Chiarini, Gaetano D'Anniballe, Fabio Marinelli, Emanuela Pietropaolo

Affiliation

¹ Dipartimento di Scienze Fisiche e Chimiche, Università di L'Aquila , Via Vetoio 67010 Coppito (AQ), Italy.

PMID: 24588108
DOI: 10.1021/ol500401p

Abstract

An unusual Brønsted acid catalyzed cascade reaction of 2-[(2-aminophenyl)ethynyl]phenylamine derivatives with aryl(heteroaryl)aldehydes to afford an efficient alternative entry into 2,2'-disubstituted-1H,1'H-3,3'-biindoles under metal-free conditions is reported.