Interstitial pneumonitis in allogeneic bone marrow transplantation: a report from the Japanese BMT Study Group

Bone Marrow Transplant. 1986 Dec;1(2):179-83.

Abstract

One hundred and four patients with acute leukemia treated by allogeneic bone marrow transplantation in Japan were analysed for the incidence of interstitial pneumonitis (IP). Thirty-six (35%) of 104 marrow graft recipients developed IP. Cytomegalovirus (CMV) was the most frequent organism (61%). Using multivariate analysis, remission at transplant (P = 0.0001) and use of cyclosporin A to prevent graft-versus-host disease (P = 0.0363) were found to be significant factors associated with a decreased incidence of IP. For preventing IP, anti-CMV hyperimmune globulin was effective, while interferon and acyclovir were not.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyclovir / therapeutic use
  • Adolescent
  • Adult
  • Bone Marrow Transplantation*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Immune Sera / administration & dosage
  • Immunoglobulins*
  • Immunoglobulins, Intravenous
  • Interferons / therapeutic use
  • Japan
  • Leukemia, Myeloid, Acute / complications
  • Leukemia, Myeloid, Acute / surgery
  • Male
  • Middle Aged
  • Patient Isolation
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / surgery
  • Pulmonary Fibrosis / epidemiology*
  • Pulmonary Fibrosis / etiology
  • Pulmonary Fibrosis / mortality
  • Transplantation, Homologous / adverse effects

Substances

  • Immune Sera
  • Immunoglobulins
  • Immunoglobulins, Intravenous
  • cytomegalovirus-specific hyperimmune globulin
  • Interferons
  • Acyclovir