Preparation of hemocompatible cellulosic paper based on P(DMAPS)-functionalized surface

Colloids Surf B Biointerfaces. 2014 Apr 1:116:537-43. doi: 10.1016/j.colsurfb.2014.01.048. Epub 2014 Feb 6.

Abstract

The surface-modification of paper substrates with functional layers is gaining increasing interest, both from academic and industrial research. In this case, the cellulosic paper (CP) surface was functionalized with zwitterionic poly-(3-dimethyl(methacryloyloxyethyl) ammoniumpropane sulfonate) (CP-g-P(DMAPS) via surface-initiated atom transfer radical polymerization (ATRP) technique for enhancing blood compatibility. An obvious increase in graft yield of the functional P(DMAPS) with polymerization time was observed. The new CP-g-P(DMAPS) produced was investigated for its hemocompatibility. The hemocompatibility studied including platelet and whole blood ceels adhesion tests, hemolysis assay, morphological changes of red blood cells (RBCs), coagulation time tests, and complement activation, platelet activation at the molecular level. Most assays had remarkable differences in the presence of the new zwitterionic CP, indicated the importance of the zwitterion for hemocompatibility of CP.

Keywords: ATRP; Cellulosic paper; Hemocompatibility; P(DMAPS); Surface modification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry*
  • Biocompatible Materials / pharmacology
  • Blood Coagulation Tests
  • Blood Platelets / drug effects
  • Cellulose / chemistry*
  • Erythrocytes / drug effects
  • Paper*
  • Particle Size
  • Platelet Activation / drug effects
  • Platelet Adhesiveness / drug effects
  • Polymethacrylic Acids / chemistry*
  • Quaternary Ammonium Compounds / chemistry*
  • Rabbits
  • Surface Properties

Substances

  • Biocompatible Materials
  • Polymethacrylic Acids
  • Quaternary Ammonium Compounds
  • Cellulose