Activity of caffeic acid derivatives against Candida albicans biofilm

Daniela De Vita; Laura Friggeri; Felicia Diodata D'Auria; Fabiana Pandolfi; Francesco Piccoli; Simona Panella; Anna Teresa Palamara; Giovanna Simonetti; Luigi Scipione; Roberto Di Santo; Roberta Costi; Silvano Tortorella

doi:10.1016/j.bmcl.2014.02.005

Activity of caffeic acid derivatives against Candida albicans biofilm

Bioorg Med Chem Lett. 2014 Mar 15;24(6):1502-5. doi: 10.1016/j.bmcl.2014.02.005. Epub 2014 Feb 13.

Affiliations

¹ Department of 'Chimica e Tecnologie del Farmaco', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
² Department of 'Sanità Pubblica e Malattie Infettive', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
³ Department of 'Sanità Pubblica e Malattie Infettive', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy. Electronic address: giovanna.simonetti@uniroma1.it.
⁴ Department of 'Chimica e Tecnologie del Farmaco', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy. Electronic address: luigi.scipione@uniroma1.it.
⁵ 'Istituto Pasteur-Fondazione Cenci Bolognetti', Department of 'Chimica e Tecnologie del Farmaco', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.

PMID: 24582984
DOI: 10.1016/j.bmcl.2014.02.005

Abstract

The aim of this study was to evaluate the caffeic acid (1) and ester derivatives (2-10) against Candida albicans biofilm and to investigate whether these compounds are able to inhibit the biofilm formation or destroy pre-formed biofilm. Caffeic acid ester 7, cinnamic acid ester 8 and 3,4-dihydroxybenzoic acid ester 10 are more active than fluconazole, used as reference drug, both on biofilm in formation with MIC50 values of 32, 32 and 16μg/mL, respectively, and in the early stage of biofilm formation (4h) with MIC50 values of 64, 32 and 64μg/mL, respectively. These esters result also more active than fluconazole on mature biofilm (24h), especially 8 and 10 with MIC50 values of 64μg/mL.

Keywords: Anti-biofilm agents; Biofilm formation; Caffeic acid; Candida albicans biofilm.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis
Antifungal Agents / chemistry*
Antifungal Agents / pharmacology*
Biofilms / drug effects*
Caffeic Acids / chemical synthesis
Caffeic Acids / chemistry*
Caffeic Acids / pharmacology*
Candida albicans / physiology*
Cell Line, Tumor
Cell Survival / drug effects
Humans
Microbial Sensitivity Tests

Substances

Antifungal Agents
Caffeic Acids
caffeic acid