Non-homologous end joining: emerging themes and unanswered questions

DNA Repair (Amst). 2014 May:17:2-8. doi: 10.1016/j.dnarep.2014.01.009. Epub 2014 Feb 26.

Abstract

Non-homologous end joining (NHEJ) is the major pathway for the repair of ionizing radiation induced DNA double strand breaks in human cells. Here, we discuss current insights into the mechanism of NHEJ and the interplay between NHEJ and other pathways for repair of IR-induced DNA damage.

Keywords: DNA double strand break repair; Ionizing radiation; Non-homologous end joining.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Cycle
  • DNA Breaks, Double-Stranded / radiation effects*
  • DNA End-Joining Repair*
  • DNA Repair Enzymes / metabolism
  • DNA-Activated Protein Kinase / metabolism*
  • Humans
  • Nuclear Proteins / metabolism

Substances

  • Nuclear Proteins
  • DNA-Activated Protein Kinase
  • DNA Repair Enzymes