Monoterpene glycosides, phenylpropanoids, and acacetin glycosides from Dracocephalum foetidum

Erdenechimeg Selenge; Toshihiro Murata; Shiho Tanaka; Kenroh Sasaki; Javzan Batkhuu; Fumihiko Yoshizaki

doi:10.1016/j.phytochem.2014.02.007

Monoterpene glycosides, phenylpropanoids, and acacetin glycosides from Dracocephalum foetidum

Phytochemistry. 2014 May:101:91-100. doi: 10.1016/j.phytochem.2014.02.007. Epub 2014 Feb 28.

Authors

Erdenechimeg Selenge¹, Toshihiro Murata², Shiho Tanaka¹, Kenroh Sasaki¹, Javzan Batkhuu³, Fumihiko Yoshizaki¹

Affiliations

¹ Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-1 Komatsushima 4-chome Aoba-ku, Sendai 981-8558, Japan.
² Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-1 Komatsushima 4-chome Aoba-ku, Sendai 981-8558, Japan. Electronic address: murata-t@tohoku-pharm.ac.jp.
³ School of Biology and Biotechnology, National University of Mongolia, PO Box 617, Ulaanbaatar 46A, Mongolia.

PMID: 24582463
DOI: 10.1016/j.phytochem.2014.02.007

Abstract

Chemical investigation of the acetone extract from the aerial parts of the Mongolian medicinal plant Dracocephalum foetidum resulted in the isolation of three limonene glycosides, a caffeic acid trimer, four rosmarinic acid glucosides, and five acacetin acyl glycosides, together with 13 known natural products. The chemical structures of all of the compounds were determined by spectroscopic analyses. Among these compounds three showed hyaluronidase inhibitory activity. In addition, one other compound showed stronger 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity than the positive control Trolox, whereas three other compounds demonstrated a similar activity to that of Trolox.

Keywords: DPPH radical scavenging activity; Dracocephalum foetidum; Hyaluronidase inhibitory activity; Lamiaceae; Limonene glycoside; Phenylpropanoid.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants / isolation & purification*
Biphenyl Compounds / chemistry
Flavones / isolation & purification*
Glycosides / isolation & purification*
Hyaluronoglucosaminidase / antagonists & inhibitors
Lamiaceae / chemistry*
Medicine, Mongolian Traditional
Mongolia
Monoterpenes / isolation & purification*
Picrates / chemistry
Plant Components, Aerial / chemistry
Plant Extracts / isolation & purification
Plants, Medicinal
Propanols / isolation & purification*

Substances

Antioxidants
Biphenyl Compounds
Flavones
Glycosides
Monoterpenes
Picrates
Plant Extracts
Propanols
1-phenylpropanol
1,1-diphenyl-2-picrylhydrazyl
Hyaluronoglucosaminidase
acacetin