Metabolic white matter diseases and the utility of MR spectroscopy

Macey D Bray; Mark E Mullins

doi:10.1016/j.rcl.2013.11.012

Metabolic white matter diseases and the utility of MR spectroscopy

Radiol Clin North Am. 2014 Mar;52(2):403-11. doi: 10.1016/j.rcl.2013.11.012.

Authors

Macey D Bray¹, Mark E Mullins²

Affiliations

¹ Department of Radiology, University of New Mexico, MSC10 5530, 1 University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: mbray@atsu.edu.
² Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road Northeast, Room D125A, Atlanta, GA 30345, USA.

PMID: 24582346
DOI: 10.1016/j.rcl.2013.11.012

Abstract

Magnetic resonance spectroscopy (MRS) can be useful as an adjuvant diagnostic tool to traditional MR imaging of the brain. MRS can provide both quantitative and qualitative information about white matter pathologic abnormality. It is important to interpret MRS in conjunction with other clinical factors including but not limited to additional diagnostic neuroimaging, history and physical examination findings, and genetics.

Keywords: Brain tumor; Demyelination; Inborn errors of metabolism; Leukodystrophy; MR Spectroscopy (MRS); Mitochondrial disorders; Radiation therapy; Voxel.

Publication types

Review

MeSH terms

Brain Diseases, Metabolic / diagnosis*
Brain Diseases, Metabolic / pathology
Diagnosis, Differential
Humans
Leukoencephalopathies / diagnosis*
Magnetic Resonance Spectroscopy / methods*