Platelet activation by riboflavin and UV light: is it really the other side of the coin?

Gianpaolo Del Proposto; Alessandro Lanti; Eleonora Fiorelli; Gloria Palazzo; Giorgia Guiducci; Francesca Messina; Alessandra De Masi; Angelo Salvatore Ferraro; Oana Marilena Chiru; Paola Cerrone; Maddalena Antonelli; Gaspare Adorno

doi:10.1016/j.transci.2014.01.020

Platelet activation by riboflavin and UV light: is it really the other side of the coin?

Transfus Apher Sci. 2014 Apr;50(2):207-9. doi: 10.1016/j.transci.2014.01.020. Epub 2014 Feb 15.

Affiliations

¹ SIMT Tor Vergata Hospital, Rome, Italy. Electronic address: delpropostog@gmail.com.
² SIMT Tor Vergata Hospital, Rome, Italy. Electronic address: ale.lanti@libero.it.
³ Immunohematology Section, Tor Vergata University, Rome, Italy. Electronic address: elefiorelli@hotmail.it.
⁴ Immunohematology Section, Tor Vergata University, Rome, Italy. Electronic address: gloriapalazzo3010@gmail.com.
⁵ Immunohematology Section, Tor Vergata University, Rome, Italy. Electronic address: giorgiaguiducci@yahoo.it.
⁶ SIMT Tor Vergata Hospital, Rome, Italy. Electronic address: messinafrancesca@virgilio.it.
⁷ Immunohematology Section, Tor Vergata University, Rome, Italy. Electronic address: demasialessandra@gmail.com.
⁸ SIMT Tor Vergata Hospital, Rome, Italy. Electronic address: angelosalvatore.ferraro@gmail.com.
⁹ Immunohematology Section, Tor Vergata University, Rome, Italy. Electronic address: oanaafl@gmail.com.
¹⁰ SIMT Tor Vergata Hospital, Rome, Italy. Electronic address: laugiu9799@libero.it.
¹¹ Immunohematology Section, Tor Vergata University, Rome, Italy. Electronic address: magda.antonelli@libero.it.
¹² SIMT Tor Vergata Hospital, Rome, Italy; Immunohematology Section, Tor Vergata University, Rome, Italy. Electronic address: medtras@libero.it.

PMID: 24582055
DOI: 10.1016/j.transci.2014.01.020

Abstract

Introduction: Nowadays transfusion safety is still put at risk by contamination of pathogens. The Mirasol PRT System blocks the replication of pathogens and white blood cells. Our goal was to quantify the activation of platelets after treatment with the Mirasol device.

Materials and methods: From September to December 2013, 131 platelet collections were studied using a simple flow cytometric strategy.

Results: There was a significant correlation between the percentage of platelet activated before and after the treatment.

Conclusion: Our results induced us to think that the activation of platelets after treatment was acceptable.

Keywords: Annexin V; Glycoproteins IIb/IIIa; Platelet collections; Riboflavin; UV light.

MeSH terms

Adult
Blood Platelets / cytology
Blood Platelets / metabolism*
Female
Humans
Male
Middle Aged
Photosensitizing Agents / pharmacology*
Platelet Activation* / drug effects
Platelet Activation* / radiation effects
Riboflavin / pharmacology*
Ultraviolet Rays*

Substances

Photosensitizing Agents
Riboflavin