Dual-histidine kinases in basidiomycete fungi

José L Lavín; Vanessa Sarasola-Puente; Lucía Ramírez; Antonio G Pisabarro; José A Oguiza

doi:10.1016/j.crvi.2013.12.007

Dual-histidine kinases in basidiomycete fungi

C R Biol. 2014 Feb;337(2):111-6. doi: 10.1016/j.crvi.2013.12.007. Epub 2014 Feb 10.

Authors

José L Lavín¹, Vanessa Sarasola-Puente², Lucía Ramírez², Antonio G Pisabarro², José A Oguiza³

Affiliations

¹ Genome Analysis Platform, Functional Genomics Unit, CIC bioGUNE, Bizkaia Technology Park, Building 502, 48160 Derio, Spain.
² Genetics and Microbiology Research Group, Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain.
³ Genetics and Microbiology Research Group, Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain. Electronic address: jose.oguiza@unavarra.es.

PMID: 24581805
DOI: 10.1016/j.crvi.2013.12.007

Abstract

Dual-histidine kinases (HKs) are complex hybrid HKs containing in a single polypeptide two HK transmitter modules (T) and two-response regulator received domains (R) that are combined in a TRTR geometry. In fungi, this protein family is limited to some particular species of the phylum Basidiomycota and absent in the other phyla. This study extends the investigation of dual-HKs to 80 fully sequenced genomes of basidiomycetes, analyzing their distribution, domain architecture and phylogenetic relationships. Moreover, similarly to dual-HKs of basidiomycetes, several species of bacteria were found that contain hybrid HKs with a TRTR domain architecture encoded in a single gene.

Keywords: Basidiomycetes; Comparative genomics; Genomic analysis; Histidine kinase; Signal transduction; Two-component system.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Basidiomycota / enzymology*
Basidiomycota / genetics
Genes, Fungal
Genome, Fungal
Histidine Kinase
Protein Kinases / genetics
Protein Kinases / metabolism*
Proteome
Signal Transduction / physiology

Substances

Proteome
Protein Kinases
Histidine Kinase