Ribosome rescue, nearing the end

Agata L Starosta; Daniel N Wilson

doi:10.1016/j.cell.2014.02.028

Ribosome rescue, nearing the end

Cell. 2014 Feb 27;156(5):866-7. doi: 10.1016/j.cell.2014.02.028.

Authors

Agata L Starosta¹, Daniel N Wilson²

Affiliations

¹ Gene Center, Department for Biochemistry and Center for integrated Protein Science Munich (CiPSM), University of Munich, 81377 Munich, Germany.
² Gene Center, Department for Biochemistry and Center for integrated Protein Science Munich (CiPSM), University of Munich, 81377 Munich, Germany. Electronic address: wilson@lmb.uni-muenchen.de.

PMID: 24581485
DOI: 10.1016/j.cell.2014.02.028

Abstract

In eukaryotes, Dom34 is involved in the rescue of ribosomes that stall on mRNAs during protein synthesis. Using ribosome profiling, Guydosh and Green reveal that, in addition to rescue of ribosomes stalled on truncated mRNAs, Dom34 also recycles ribosomes that are unexpectedly found in the 3' untranslated regions of many cellular mRNAs.

Publication types

Comment

MeSH terms

3' Untranslated Regions*
Cell Cycle Proteins / metabolism*
Endoribonucleases / metabolism*
Ribosomes / metabolism*
Saccharomyces cerevisiae / metabolism*
Saccharomyces cerevisiae Proteins / metabolism*

Substances

3' Untranslated Regions
Cell Cycle Proteins
Saccharomyces cerevisiae Proteins
Dom34 protein, S cerevisiae
Endoribonucleases