The process of crystallization in the urinary tract occurs when the equilibrium between promoting and inhibiting factors is broken. Many theories have been published to explain the mechanism of urinary stones formation; however, none of these theories has paid attention to trace elements. Their role in lithogenesis is still unclear and under debate. The findings of some studies may support the thesis that some major and trace elements may take part in the initiation of stone crystallization for instance as a nucleus or nidus for the formation of the stone, or simply contaminate the stone structure. This review presents a comprehensive account of the basic principles of the basic data and the role of major and trace elements in lithogenesis.
Keywords: pathogenesis; trace elements; urinary stone.