Evidence of Clonal Expansion in the Genome of a Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolate from Peru

M Galarza; D Tarazona; V Borda; J C Agapito; H Guio

doi:10.1128/genomeA.00089-14

Evidence of Clonal Expansion in the Genome of a Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolate from Peru

Genome Announc. 2014 Feb 27;2(1):e00089-14. doi: 10.1128/genomeA.00089-14.

Authors

M Galarza¹, D Tarazona, V Borda, J C Agapito, H Guio

Affiliation

¹ Laboratorio de Biotecnología y Biología Molecular, Instituto Nacional de Salud, Lima, Peru.

Abstract

We report the genome sequence of Mycobacterium tuberculosis INS-MDR from Peru, a multidrug-resistant tuberculosis (MDR-TB) and Latin American-Mediterranean (LAM) lineage strain. Our analysis showed mutations related to drug resistance in the rpoB (D516V), katG (S315T), kasA (G269S), and pncA (Q10R) genes. Our evidence suggests that INS-MDR may be a clonal expansion related to the African strain KZN 1435.