Thermoelastic displacement measured by DP-OCT for detecting vulnerable plaques

Jihoon Kim; Hyun Wook Kang; Junghwan Oh; Thomas E Milner

doi:10.1364/BOE.5.000474

Thermoelastic displacement measured by DP-OCT for detecting vulnerable plaques

Biomed Opt Express. 2014 Jan 14;5(2):474-84. doi: 10.1364/BOE.5.000474. eCollection 2014 Feb 1.

Authors

Jihoon Kim¹, Hyun Wook Kang², Junghwan Oh², Thomas E Milner³

Affiliations

¹ Fundamental Technology Group, Samsung-Electro Mechanics, Suwon 443-743, South Korea.
² Department of Biomedical Engineering, Pukyong National University, Busan 608-737, South Korea ; Center for Marine-Integrated Biomedical Technology, Pukyong National University, Busan 608-737, South Korea.
³ Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA.

Abstract

The detection of thermoelastic displacement by differential phase optical coherence tomography (DP-OCT) was analytically evaluated for identifying atherosclerotic plaques. Analytical solutions were developed to understand the dynamics of physical distribution of point hear sources during/after laser irradiation on thermoelastic responses of MION-injected tissue. Both analytical and experimental results demonstrated a delayed peak displacement along with slow decay after laser pulse due to heterogeneous distribution of the point heat sources. Detailed description of the heat sources in tissue as well as integration of a scanning mirror can improve computational accuracy as well as clinical applicability of DP-OCT for diagnosing vulnerable plaque.

Keywords: (000.1430) Biology and medicine; (120.3890) Medical optics instrumentation; (170.4500) Optical coherence tomography; (350.5340) Photothermal effects.