Modification of biomaterials with a self-protein inhibits the macrophage response

Adv Healthc Mater. 2014 Jul;3(7):989-94. doi: 10.1002/adhm.201300532. Epub 2014 Feb 20.

Abstract

A biomaterial inhibits the host immune response by displaying an endo-genously expressed immunomodulatory molecule, CD200. Immobilization of CD200 onto biomaterial surfaces effectively suppresses macrophage activation and reduces inflammatory response to subcutaneously implanted materials.

Keywords: biocompatibility; biomaterials; host response; immunomodulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adsorption
  • Animals
  • Antigens, CD / chemistry
  • Antigens, CD / pharmacology*
  • Biocompatible Materials / chemistry*
  • Female
  • Humans
  • Immobilized Proteins / chemistry
  • Immobilized Proteins / pharmacology*
  • Inflammation
  • Macrophages / cytology
  • Macrophages / drug effects*
  • Macrophages / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Skin / chemistry

Substances

  • Antigens, CD
  • Biocompatible Materials
  • Immobilized Proteins
  • antigens, CD200