Alternative macroautophagy and mitophagy

Shigeomi Shimizu; Shinya Honda; Satoko Arakawa; Hirofumi Yamaguchi

doi:10.1016/j.biocel.2014.02.016

Alternative macroautophagy and mitophagy

Int J Biochem Cell Biol. 2014 May:50:64-6. doi: 10.1016/j.biocel.2014.02.016. Epub 2014 Feb 22.

Authors

Shigeomi Shimizu¹, Shinya Honda², Satoko Arakawa², Hirofumi Yamaguchi²

Affiliations

¹ Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. Electronic address: shimizu.pcb@mri.tmd.ac.jp.
² Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

PMID: 24569119
DOI: 10.1016/j.biocel.2014.02.016

Abstract

Mitophagy is a mitochondrial quality control mechanism where damaged and surplus mitochondria are removed by macroautophagy. Mitophagy is associated with various physiological and pathological events such as mitochondrial clearance during terminal differentiation of reticulocytes. There are two different mammalian macroautophagy pathways: the Atg5-dependent conventional pathway and an Atg5-independent alternative pathway; the latter is involved in the erythrocyte mitophagy.

Keywords: Atg5-independent macroautophagy; Erythrocyte maturation; Mitophagy; Parkin; Selective autophagy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Autophagy / drug effects
Autophagy / physiology*
Cell Differentiation
Homeostasis
Humans
Mitochondria / physiology*