Acetate/acetyl-CoA metabolism associated with cancer fatty acid synthesis: overview and application

Cancer Lett. 2015 Jan 28;356(2 Pt A):211-6. doi: 10.1016/j.canlet.2014.02.019. Epub 2014 Feb 22.

Abstract

Understanding cancer-specific metabolism is important for identifying novel targets for cancer diagnosis and therapy. Induced acetate/acetyl CoA metabolism is a notable feature that is related to fatty acid synthesis supporting tumor growth. In this review, we focused on the recent findings related to cancer acetate/acetyl CoA metabolism. We also introduce [1-¹¹C]acetate positron emission tomography (PET), which is a useful tool to visualize up-regulation of acetate/acetyl CoA metabolism in cancer, and discuss the utility of [1-¹¹C]acetate PET in cancer diagnosis and its application to personalized medicine.

Keywords: Acetate; Acetyl CoA; Fatty acid; Metabolism; Positron emission tomography.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetates / metabolism*
  • Acetyl Coenzyme A / metabolism*
  • Cell Hypoxia
  • Coenzyme A Ligases / metabolism
  • Fatty Acids / biosynthesis*
  • Humans
  • Lipogenesis / physiology
  • Neoplasms / diagnosis*
  • Neoplasms / metabolism*
  • Positron-Emission Tomography / methods
  • Precision Medicine
  • Up-Regulation

Substances

  • Acetates
  • Fatty Acids
  • Acetyl Coenzyme A
  • Coenzyme A Ligases
  • acetate-CoA ligase (ADP-forming)