Abstract
A new sesquiterpenoid, malayscaphiol (1), and three known compounds, lupeol (2), lupenone (3) and stigmasterol (4), were isolated from the methanolic extract of the stem bark of Scaphium macropodum. The structures of the isolated compounds were determined using several spectroscopic methods, including UV-vis, FT-IR, 1D and 2D NMR, and mass spectrometer. Major isolated compounds were assayed for cytotoxicity and anti-acetylcholinesterase activities. The chemotaxonomy significance of this plant was also discussed.
Keywords:
Scaphium macropodum; Sterculiaceae; anti-acetylcholinesterase; cytotoxicity; malayscaphiol; sesquiterpenoid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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Malaysia
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Malvaceae / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Pentacyclic Triterpenes / chemistry
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Pentacyclic Triterpenes / isolation & purification
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Plant Bark / chemistry
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Polycyclic Compounds / chemistry
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Polycyclic Compounds / isolation & purification*
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Polycyclic Compounds / pharmacology
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Spectroscopy, Fourier Transform Infrared
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Stigmasterol / chemistry
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Stigmasterol / isolation & purification
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Triterpenes / chemistry
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Triterpenes / isolation & purification
Substances
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Antineoplastic Agents, Phytogenic
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Pentacyclic Triterpenes
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Polycyclic Compounds
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Sesquiterpenes
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Triterpenes
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lupenone
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malayscaphiol
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Stigmasterol
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lupeol