Binding modes of chain arylpiperazines to 5-HT1a, 5-HT2a and 5-HT7 receptors

Mini Rev Med Chem. 2013 Aug;13(10):1516-39. doi: 10.2174/1389557511313100012.

Abstract

An overview of docking models of chain arylpiperazines to different subtypes of serotonin receptors belonging to the GPCR family is presented. The theory of a ligand-receptor interaction has been briefly summarized. The review covers more than twenty models, beginning with the early models of a ligand interaction with the 5-HT1A and 5-HT2A receptor, and ending with a ligand-5-HT7 receptor docking studies.

Publication types

  • Review

MeSH terms

  • Binding Sites / drug effects
  • Humans
  • Ligands
  • Models, Molecular
  • Piperazines / chemistry*
  • Piperazines / pharmacology
  • Receptor, Serotonin, 5-HT1A / chemistry*
  • Receptor, Serotonin, 5-HT1A / metabolism
  • Receptor, Serotonin, 5-HT2A / chemistry*
  • Receptor, Serotonin, 5-HT2A / metabolism
  • Receptors, Serotonin / chemistry*
  • Receptors, Serotonin / metabolism
  • Serotonin 5-HT1 Receptor Agonists / chemistry
  • Serotonin 5-HT1 Receptor Agonists / pharmacology
  • Serotonin 5-HT1 Receptor Antagonists / chemistry
  • Serotonin 5-HT1 Receptor Antagonists / pharmacology
  • Serotonin 5-HT2 Receptor Agonists / chemistry
  • Serotonin 5-HT2 Receptor Agonists / pharmacology
  • Serotonin 5-HT2 Receptor Antagonists / chemistry
  • Serotonin 5-HT2 Receptor Antagonists / pharmacology
  • Structure-Activity Relationship

Substances

  • Ligands
  • Piperazines
  • Receptor, Serotonin, 5-HT2A
  • Receptors, Serotonin
  • Serotonin 5-HT1 Receptor Agonists
  • Serotonin 5-HT1 Receptor Antagonists
  • Serotonin 5-HT2 Receptor Agonists
  • Serotonin 5-HT2 Receptor Antagonists
  • serotonin 7 receptor
  • Receptor, Serotonin, 5-HT1A