Abstract
An overview of docking models of chain arylpiperazines to different subtypes of serotonin receptors belonging to the GPCR family is presented. The theory of a ligand-receptor interaction has been briefly summarized. The review covers more than twenty models, beginning with the early models of a ligand interaction with the 5-HT1A and 5-HT2A receptor, and ending with a ligand-5-HT7 receptor docking studies.
MeSH terms
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Binding Sites / drug effects
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Humans
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Ligands
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Models, Molecular
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Piperazines / chemistry*
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Piperazines / pharmacology
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Receptor, Serotonin, 5-HT1A / chemistry*
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Receptor, Serotonin, 5-HT1A / metabolism
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Receptor, Serotonin, 5-HT2A / chemistry*
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Receptor, Serotonin, 5-HT2A / metabolism
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Receptors, Serotonin / chemistry*
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Receptors, Serotonin / metabolism
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Serotonin 5-HT1 Receptor Agonists / chemistry
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Serotonin 5-HT1 Receptor Agonists / pharmacology
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Serotonin 5-HT1 Receptor Antagonists / chemistry
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Serotonin 5-HT1 Receptor Antagonists / pharmacology
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Serotonin 5-HT2 Receptor Agonists / chemistry
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Serotonin 5-HT2 Receptor Agonists / pharmacology
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Serotonin 5-HT2 Receptor Antagonists / chemistry
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Serotonin 5-HT2 Receptor Antagonists / pharmacology
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Structure-Activity Relationship
Substances
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Ligands
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Piperazines
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Receptor, Serotonin, 5-HT2A
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Receptors, Serotonin
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Serotonin 5-HT1 Receptor Agonists
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Serotonin 5-HT1 Receptor Antagonists
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Serotonin 5-HT2 Receptor Agonists
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Serotonin 5-HT2 Receptor Antagonists
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serotonin 7 receptor
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Receptor, Serotonin, 5-HT1A