T1 mapping in ischaemic heart disease

Eur Heart J Cardiovasc Imaging. 2014 Jun;15(6):597-602. doi: 10.1093/ehjci/jeu024. Epub 2014 Feb 23.

Abstract

A unique feature of cardiac magnetic resonance is its ability to characterize myocardium. Proton relaxation times, T1, T2, and T2* are a reflection of the composition of individual tissues, and change in the presence of disease. Research into T1 mapping has largely been focused in the study of cardiomyopathies, but T1 mapping also shows huge potential in the study of ischaemic heart disease. In fact, the first cardiac T1 maps were used to characterize myocardial infarction. Robust high-resolution myocardial T1 mapping is now available for use as a clinical tool. This quantitative technique is simple to perform and analyse, minimally subjective, and highly reproducible. This review aims to summarize the present state of research on the topic, and to show the clinical potential of this method to aid the diagnosis and treatment of patients with ischaemic heart disease.

Keywords: ECV; Ischaemic heart disease; Myocardial infarction; Myocardial ischaemia; T1 Mapping.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Female
  • Gadolinium DTPA*
  • Humans
  • Image Processing, Computer-Assisted*
  • Magnetic Resonance Imaging, Cine / methods*
  • Male
  • Myocardial Infarction / diagnosis
  • Myocardial Ischemia / diagnosis*
  • Sensitivity and Specificity

Substances

  • Gadolinium DTPA