Krempfielins N-P, New anti-inflammatory eunicellins from a Taiwanese soft coral Cladiella krempfi

Mar Drugs. 2014 Feb 21;12(2):1148-56. doi: 10.3390/md12021148.

Abstract

Three new eunicellin-type diterpenoids, krempfielins N-P (1-3), were isolated from a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compound 3 exhibited activity to inhibit superoxide anion generation. Both 1 and 3, in particular 1, were shown to display significant anti-inflammatory activity by inhibiting the elastase release in FMLP/CB-induced human neutrophils.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology*
  • Cytochalasin B / pharmacology
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Humans
  • N-Formylmethionine Leucyl-Phenylalanine / pharmacology
  • Neutrophils / drug effects*
  • Neutrophils / metabolism
  • Pancreatic Elastase / metabolism
  • Spectrum Analysis
  • Taiwan

Substances

  • Anti-Inflammatory Agents
  • Diterpenes
  • eunicellin
  • krempfielin N
  • krempfielin O
  • krempfielin P
  • Cytochalasin B
  • N-Formylmethionine Leucyl-Phenylalanine
  • Pancreatic Elastase