Characterization and treatment of postsurgical dental implant pain employing intranasal ketorolac

Rebecca Bockow; Jonathan Korostoff; Andres Pinto; Matthew Hutcheson; Stacey A Secreto; Laura Bodner; Elliot V Hersh

Characterization and treatment of postsurgical dental implant pain employing intranasal ketorolac

Compend Contin Educ Dent. 2013 Sep;34(8):570-6.

Authors

Rebecca Bockow¹, Jonathan Korostoff², Andres Pinto³, Matthew Hutcheson⁴, Stacey A Secreto⁵, Laura Bodner⁶, Elliot V Hersh⁷

Affiliations

¹ Resident in orthodontics and periodontics, Departments of Orthodontics and Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
² Associate Professor of Periodontics, Director of the Master of Science in Oral Biology Program, Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
³ Associate Professor of Oral Medicine and Community Oral Health, Director of Oral Medicine Services and Chief, Division of Community Oral Health, Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
⁴ Adjunct Professor, Departments of Education, Widener University, Chester, Pennsylvania, and Delaware Valley College, Doylestown, Pennsylvania, Partner, Tegra Analytics, Doylestown, Pennsylvania.
⁵ Clinical Research Coordinator, Department of Oral Surgery and Pharmacology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
⁶ Resident, Department of Orthodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
⁷ Director, Division of Pharmacology and Therapeutics, Professor, Oral and Maxillofacial Surgery and Pharmacology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

PMID: 24564610

Abstract

The intensity and duration of pain following surgical placement of dental implants has not been well studied. Thus, the aim of this open-label study was to characterize the nature of postsurgical pain following the placement of one to three implants. The secondary goal was to explore the analgesic efficacy and tolerability of intranasal ketorolac in this patient population. Following implant surgery, postoperative pain was rated moderate or severe in 25/28 patients (89 percent), requiring prn analgesic dosing for up to 3 days in 14/25 individuals (56 percent). Intranasal ketorolac displayed an analgesic onset within 20 minutes, a duration of at least 6 hours, and was well tolerated by the cohort with brief stinging of the nasal mucosa reported by 9/25 individuals (36 percent).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetaminophen / therapeutic use
Administration, Intranasal
Adult
Analgesia, Patient-Controlled / methods
Analgesics, Non-Narcotic / therapeutic use
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Anti-Inflammatory Agents, Non-Steroidal / adverse effects
Cohort Studies
Dental Implantation, Endosseous*
Dental Implants
Female
Humans
Ketorolac / administration & dosage*
Ketorolac / adverse effects
Male
Middle Aged
Nasal Mucosa / drug effects
Operative Time
Pain Measurement
Pain, Postoperative / drug therapy*
Pilot Projects
Rhinitis / chemically induced
Time Factors
Treatment Outcome
Young Adult

Substances

Analgesics, Non-Narcotic
Anti-Inflammatory Agents, Non-Steroidal
Dental Implants
Acetaminophen
Ketorolac