Chemical composition and bioactivities of flavonoids-rich extract from Davallia cylindrica Ching

Environ Toxicol Pharmacol. 2014 Mar;37(2):571-9. doi: 10.1016/j.etap.2014.01.011. Epub 2014 Jan 28.

Abstract

The flavonoids profiles and bioactivities of flavonoids-rich extract from Davallia cylindrica Ching were investigated. The total flavonoids content in D. cylindrica was determined as about 164.41 mg/g. The main flavonoids in D. cylindrica were tentatively identified as quercetin-3-O-rutinoside, quercetin 7-O-glucoside, quercetin 7-O-glucoside, kaempferol 3-O-rutinoside, and quercitrin by UV and ESI-MS spectra. Flavonoids-rich extract (0.258 mg/ml) from D. cylindrica showed similar or higher free radical (O2(-), DPPH and ABTS) scavenging potential with that of rutin (0.25 mg/ml). The reducing power of flavonoids-rich extract (0.258 mg/ml) was slightly stronger than that of 0.25mg/ml rutin. The flavonoids extract from D. cylindrica exhibited cytotoxic effects on A549 cells. It exhibited a dose-dependent inhibition against acetylcholinesterase.

Keywords: Acetylcholinesterase inhibitor; Anticancer; Antioxidant; Davallia cylindrica; Flavonoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism
  • Antineoplastic Agents / analysis
  • Antineoplastic Agents / pharmacology*
  • Antioxidants / analysis
  • Antioxidants / pharmacology*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cholinesterase Inhibitors / analysis
  • Cholinesterase Inhibitors / pharmacology*
  • Flavonoids / analysis
  • Flavonoids / pharmacology*
  • Humans
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Superoxides / metabolism
  • Tracheophyta*

Substances

  • Antineoplastic Agents
  • Antioxidants
  • Cholinesterase Inhibitors
  • Flavonoids
  • Plant Extracts
  • Superoxides
  • Acetylcholinesterase