The aim of the study was to understand whether dietary fatty acids such as saturated, polyunsaturated, and monounsaturated fatty acids act as inflammatory mediators or influence pro-coagulation in Saudi adults. The study sought to examine inflammatory factors such as C-reactive protein, tumor necrosis factor-alpha and activated plasminogen activator inhibitor 1. A total number of 232 consenting Saudi adults, aged 18-60 years were randomly selected in this cross-sectional study. Independent Student t-test was done to compare means of normally distributed data. Spearman correlation between the variables was determined. The values of different fatty acids and adipokines were transformed logarithmically/square root to normalize data before correlations were determined and statistical analyses performed. Statistical significance was set at p<0.05. The results show a significant positive correlation of dietary intake of poly and monounsaturated fatty acids, but not saturated fatty acids, with activated plasminogen activator inhibitor 1 (r=0.31, p=0.02, r=0.32 p=0.04). On the other hand, dietary intake of saturated fatty acids showed a negative correlation with serum C-reactive protein levels (p=0.001) in males. Dietary unsaturated fatty acids is possibly associated with the production of a pro-coagulation factor without enhancing the secretion of pro-inflammatory molecules, while saturated fatty acids have no effect on activated plasminogen activator inhibitor 1, but their level is negatively associated with the inflammatory factor C-reactive protein. We conclude that dietary intake may exert a gender-specific effect in inflammatory processes among adults. Further studies are warranted to confirm present findings.
本研究目的是了解在沙烏地阿拉伯成人中，膳食脂肪酸的攝取，如：飽和、 多元不飽和以及單元不飽和脂肪酸，是否為發炎反應的調節物質或影響促凝 血。本研究檢測發炎因子像是C-反應蛋白、腫瘤壞死因子-α 和活化的Ⅰ型纖 溶酶原激活物抑制因子(aPAI-1)。在此橫斷面研究中，以隨機抽樣，總計232 位沙烏地阿拉伯成人參與，年齡介於18 到60 歲之間。以獨立Student t 檢定 比較常態分佈資料的平均值。使用斯皮爾曼係數來確定變項間的相關。進行 相關性測定之前，不同的脂肪酸和脂肪因子的數值先轉化成對數/平方根，將 數據常態化，便於統計分析。統計上的顯著設定為p 值小於0.05。研究結果 顯示，飲食攝取的多元和單元不飽和脂肪酸與aPAI-1 有顯著的正相關，但飽 和脂肪酸與其則無相關。另一方面，男性飲食攝取的飽和脂肪酸顯示與血清 中C-反應蛋白呈現負相關。膳食不飽和脂肪酸可能與產生促凝血因子而不增 加促發炎因子的分泌有關；雖然飽和脂肪酸對aPAI-1 沒有影響，但與發炎因 子C-反應蛋白呈現負相關。結論是，飲食攝取脂肪酸在成年男、女性中對發 炎過程的影響可能有別。需要未來進一步的研究確認目前的研究結果。