First report of plasmid-mediated fluoroquinolone efflux pump QepA in Escherichia coli clinical isolate ST68, in South America

Giovanna Rincón; Marcela Radice; Marta Giovanakis; Jose A Di Conza; Gabriel Gutkind

doi:10.1016/j.diagmicrobio.2014.01.007

First report of plasmid-mediated fluoroquinolone efflux pump QepA in Escherichia coli clinical isolate ST68, in South America

Diagn Microbiol Infect Dis. 2014 May;79(1):70-2. doi: 10.1016/j.diagmicrobio.2014.01.007. Epub 2014 Jan 24.

Authors

Giovanna Rincón¹, Marcela Radice², Marta Giovanakis³, Jose A Di Conza⁴, Gabriel Gutkind²

Affiliations

¹ Dpto. de Microbiología, CABA, Universidad de Buenos Aires, Buenos Aires, Argentina; Universidad Industrial de Santander, Santander, Colombia.
² Dpto. de Microbiología, CABA, Universidad de Buenos Aires, Buenos Aires, Argentina.
³ Hospital Británico, Buenos Aires, Argentina.
⁴ Dpto. de Microbiología, CABA, Universidad de Buenos Aires, Buenos Aires, Argentina; Cátedra de Microbiología General, Universidad Nacional del Litoral, Santa Fe, Argentina. Electronic address: jdiconza@gmail.com.

PMID: 24560807
DOI: 10.1016/j.diagmicrobio.2014.01.007

Abstract

This is the first report of the presence of qepA1 efflux pump gene in Escherichia coli clinical isolate from Argentina, which was associated to other plasmid-mediated quinolone resistance determinants, such as aac(6')-Ib-cr and qnrB10 and also quinolone resistance determining regions mutations.

Keywords: Fluoroquinolone resistance; PMQR; QRDR; qepA.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged, 80 and over
Argentina
DNA, Bacterial / analysis
DNA, Bacterial / genetics
Drug Resistance, Bacterial / genetics
Escherichia coli / drug effects
Escherichia coli / genetics*
Escherichia coli / metabolism
Escherichia coli Infections / microbiology*
Escherichia coli Proteins / genetics*
Female
Humans
Plasmids / genetics*

Substances

DNA, Bacterial
Escherichia coli Proteins
QepA protein, E coli