Phenotypic directed antibody selection

Chem Biol. 2014 Feb 20;21(2):170-1. doi: 10.1016/j.chembiol.2014.02.004.

Abstract

In this issue of Chemistry & Biology, Xie and colleagues describe a "phenotype directed" approach to identify antibodies that protect cells from death caused by rhinovirus infection. The cellular antibody library of 10(8) clones yielded two antibodies that prevented cell death via the same viral target: rhinovirus 3C protease.

Publication types

  • Comment

MeSH terms

  • Antibodies / immunology*
  • Humans
  • Peptide Library*

Substances

  • Antibodies
  • Peptide Library