Pilot clinical study of boron neutron capture therapy for recurrent hepatic cancer involving the intra-arterial injection of a (10)BSH-containing WOW emulsion

Hironobu Yanagie; Syushi Higashi; Koji Seguchi; Ichiro Ikushima; Mituteru Fujihara; Yasumasa Nonaka; Kazuyuki Oyama; Syoji Maruyama; Ryo Hatae; Minoru Suzuki; Shin-ichiro Masunaga; Tomoko Kinashi; Yoshinori Sakurai; Hiroki Tanaka; Natsuko Kondo; Masaru Narabayashi; Tetsuya Kajiyama; Akira Maruhashi; Koji Ono; Jun Nakajima; Minoru Ono; Hiroyuki Takahashi; Masazumi Eriguchi

doi:10.1016/j.apradiso.2014.01.014

Pilot clinical study of boron neutron capture therapy for recurrent hepatic cancer involving the intra-arterial injection of a (10)BSH-containing WOW emulsion

Appl Radiat Isot. 2014 Jun:88:32-7. doi: 10.1016/j.apradiso.2014.01.014. Epub 2014 Jan 30.

Authors

Hironobu Yanagie¹, Syushi Higashi², Koji Seguchi², Ichiro Ikushima³, Mituteru Fujihara⁴, Yasumasa Nonaka⁵, Kazuyuki Oyama⁶, Syoji Maruyama⁷, Ryo Hatae⁷, Minoru Suzuki⁸, Shin-ichiro Masunaga⁸, Tomoko Kinashi⁸, Yoshinori Sakurai⁸, Hiroki Tanaka⁸, Natsuko Kondo⁸, Masaru Narabayashi⁸, Tetsuya Kajiyama⁹, Akira Maruhashi⁸, Koji Ono⁸, Jun Nakajima¹⁰, Minoru Ono¹¹, Hiroyuki Takahashi¹², Masazumi Eriguchi⁷

Affiliations

¹ Department of Innovative Cancer Therapeutics: Alpha particle and Immuno-therapeutics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan; Department of Nuclear Engineering & Management, Graduate School of Engineering, The University of Tokyo, Japan; Cooperative Unit of Medicine & Engineering, The University of Tokyo Hospital, Tokyo, Japan. Electronic address: yanagie@my-pharm.ac.jp.
² Department of Surgery, Kojin-kai Medical City East Hospital, Miyazaki, Japan.
³ Department of Innovative Cancer Therapeutics: Alpha particle and Immuno-therapeutics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan; Kyushu Medical & Industrial Sources Foundation, Miyazaki, Japan; Department of Radiology, Miyakonojyo Metropolitan Hospital, Miyazaki, Japan.
⁴ SPG Techno Ltd. Co., Miyazaki, Japan.
⁵ Department of Surgery, Keiaikai Hoyo Hospital, Iwate, Japan.
⁶ Department of Radiology, Shin-Yamate Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
⁷ Department of Surgery, Shin-Yamate Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
⁸ Research Reactor Institute, Kyoto University, Osaka, Japan.
⁹ Department of Innovative Cancer Therapeutics: Alpha particle and Immuno-therapeutics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
¹⁰ Cooperative Unit of Medicine & Engineering, The University of Tokyo Hospital, Tokyo, Japan; Department of Respiratory Surgery, The University of Tokyo Hospital, Tokyo, Japan.
¹¹ Cooperative Unit of Medicine & Engineering, The University of Tokyo Hospital, Tokyo, Japan; Department of Cardiac Surgery, The University of Tokyo Hospital, Tokyo, Japan.
¹² Department of Nuclear Engineering & Management, Graduate School of Engineering, The University of Tokyo, Japan; Cooperative Unit of Medicine & Engineering, The University of Tokyo Hospital, Tokyo, Japan.

PMID: 24559940
DOI: 10.1016/j.apradiso.2014.01.014

Abstract

A 63-year-old man with multiple HCC in his left liver lobe was enrolled as the first patient in a pilot study of boron neutron capture therapy (BNCT) involving the selective intra-arterial infusion of a (10)BSH-containing water-in-oil-in-water emulsion ((10)BSH-WOW). The size of the tumorous region remained stable during the 3 months after the BNCT. No adverse effects of the BNCT were observed. The present results show that (10)BSH-WOW can be used as novel intra-arterial boron carriers during BNCT for HCC.

Keywords: Boron neutron capture therapy; Hepatocellular carcinoma; Intra-arterial injection; Water-in-oil-in-water emulsion.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Borohydrides / administration & dosage*
Borohydrides / chemistry
Boron Neutron Capture Therapy / methods*
Carcinoma, Hepatocellular / diagnosis
Carcinoma, Hepatocellular / radiotherapy*
Emulsions / administration & dosage
Emulsions / chemistry
Humans
Injections, Intra-Arterial
Liver Neoplasms / diagnosis
Liver Neoplasms / radiotherapy*
Male
Middle Aged
Neoplasm Recurrence, Local / diagnosis
Neoplasm Recurrence, Local / radiotherapy*
Oils / chemistry
Pilot Projects
Sulfhydryl Compounds / administration & dosage*
Sulfhydryl Compounds / chemistry
Treatment Outcome
Water / chemistry

Substances

Borohydrides
Emulsions
Oils
Sulfhydryl Compounds
Water
mercaptoundecahydrododecaborate