Hepatoprotective effects of triterpenoids from Ganoderma cochlear

J Nat Prod. 2014 Apr 25;77(4):737-43. doi: 10.1021/np400323u. Epub 2014 Feb 21.

Abstract

Two novel trinorlanostanes, cochlates A and B (1 and 2), with a 3,4-seco-9,10-seco-9,19-cyclo skeleton, as well as six new triterpenoids, fornicatins D-F (3-5) and ganodercochlearins A-C (6-8), together with five known triterpenoids (9-13), were obtained from the fruiting bodies of Ganoderma cochlear. The structural elucidation was achieved by interpretation of spectroscopic data, and compounds 2 and 7a were further characterized by X-ray crystallographic analysis. Fornicatins A, D, and F (10, 3, and 5) and fredelin (13) lowered the ALT and AST levels in HepG2 cells treated with H2O2, suggesting that they could display in vivo hepatoprotective activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • China
  • Crystallography, X-Ray
  • Ganoderma / chemistry*
  • Hep G2 Cells
  • Humans
  • Hydrogen Peroxide / analysis
  • Lanosterol / analogs & derivatives*
  • Lanosterol / chemistry
  • Lanosterol / isolation & purification*
  • Lanosterol / pharmacology*
  • Liver / drug effects*
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Triterpenes / chemistry
  • Triterpenes / pharmacology*

Substances

  • Triterpenes
  • cochlate A
  • cochlate B
  • Lanosterol
  • Hydrogen Peroxide