Early development of broadly reactive HIV-1 neutralizing activity in elite neutralizers

Tom L G M van den Kerkhof; Zelda Euler; Marit J van Gils; Brigitte D Boeser-Nunnink; Hanneke Schuitemaker; Rogier W Sanders

doi:10.1097/QAD.0000000000000228

Early development of broadly reactive HIV-1 neutralizing activity in elite neutralizers

AIDS. 2014 May 15;28(8):1237-40. doi: 10.1097/QAD.0000000000000228.

Authors

Tom L G M van den Kerkhof¹, Zelda Euler, Marit J van Gils, Brigitte D Boeser-Nunnink, Hanneke Schuitemaker, Rogier W Sanders

Affiliation

¹ aDepartment of Experimental Immunology and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam bCrucell Holland BV, Leiden cDepartment of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands dDepartment of Microbiology and Immunology, Weill Medical College, Cornell University, New York, New York eRagon Institute of MGH, MIT and Harvard, Charlestown, Massachusetts, USA.

PMID: 24556870
DOI: 10.1097/QAD.0000000000000228

Abstract

Broadly reactive neutralizing activity (brNA) against HIV-1 is observed in 10-30% of infected individuals and generally takes 2-4 years to develop. Here, we show that two elite neutralizers, infected through injecting drug use, developed brNA around the first year postseroconversion (post-SC), whereas criteria for elite brNA were fulfilled around 30 months post-SC. These results indicate that brNA does not necessarily require multiple years to develop and they should encourage the search for vaccines that can elicit protective humoral immunity.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing / immunology*
HIV Antibodies / immunology*
HIV Infections / complications
HIV Infections / immunology*
HIV-1 / immunology*
Homosexuality, Male
Humans
Immunity, Humoral
Male
Substance Abuse, Intravenous / complications

Substances

Antibodies, Neutralizing
HIV Antibodies